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The concomitant use of METHADOSE with all cytochrome P450 3A4, 2B6, 2C19, 2C9 or 2D6 inhibitors could lead to an increase in methadone plasma concentrations, which could lead to probably deadly respiratory despair. Additionally, discontinuation of concomitantly made use of cytochrome P450 3A4, 2B6, 2C19, or 2C9 inducers might also end in a rise in